Differences in effect of Mn(II), Fe(III), Co(II), and Zn(II) ions on trypsinogen activation |
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| Authors: | T Vajda K Szalkai A Garai |
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| Institution: | 1. Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran;2. Nanobiotechnology Laboratory, Biology Department, Faculty of Science, Razi University, Kermanshah, Iran;3. Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA;1. Department of Chemistry and Pharmacy, University of Sassari, Italy;2. Research Department, Innlandet Hospital, Brumunddal, Norway;3. Inland Norway University of Applied Sciences, Elverum, Norway;4. Department of Life and Environmental Sciences, University of Cagliari, Italy |
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| Abstract: | The influence of Mn2+, Fe3+, Co2+, and Zn2+ ions on the extent of trypsinogen activation has been determined for several ion concentrations at pH 7.4 and 36.4 degrees C. For the Mn2+ ion also the autocatalytic rate constants have been detected. The effect of Ca2+ has been reinvestigated for comparison purposes. The apparent dissociation constants of KMn2+ = 0.01 (M) and KCa2+ = 0.02 (M) have been found for the given metal ion-trypsinogen complexes. For Co2+ ion, however, only a slight effect and for Fe3+ and Zn2+ ions no significant effect could be detected on trypsinogen activation. The investigated ions are of empty, open, and completed d subshells of electrons and they are different also in their ionic size. The differences in effects of the ions are discussed on the basis of these factors. |
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