Antenatal Diagnosis of an XXX Female: A Dilemma for Genetic Counseling |
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| Authors: | Lawrence R Krone Lorraine L Prichard Christy L Bradshaw Oliver W Jones Raymond M Peterson Barbara K Dixson |
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| Institution: | Division of Medical Genetics, Department of Medicine, School of Medicine, University of California, La Jolla, San Diego;Regional Center for Developmental Disabilities, Children''s Health Center, San Diego |
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| Abstract: | This report describes the first antenatal diagnosis of an XXX female. Over 150 postnatal cases of XXX females have been described. There is no specific phenotype associated with the sex chromosome abnormality and most such persons are fertile. The frequency of XXX females in mental institutions is 3.9 per 1,000 female subjects whereas the frequency in consecutive newborn infants is 1.1 per 1,000 newborns. Chi-square analysis shows this difference cannot be due to chance. On the other hand, data from consecutive newborn studies suggest that intellectual development in XXX newborns is within normal range. Available evidence favors normal development in XXX female infants although the risk for developmental disabilities may be higher for the XXX than for the XX infant. |
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