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Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development
Affiliation:1. Molecular Medicine, Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India;2. Division of Structural Biology, Welcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, England;3. Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA;4. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;5. Division of Basic Medical Sciences, ICMR, New Delhi 110062, India;6. Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India;7. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA;8. National Institute of Malarial Research (NIMR), Sector 8 Dwarka, New Delhi 110077, India
Abstract:
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  • Keywords:BRD7929  co-crystal structure  drug selectivity  
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