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Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration
Affiliation:1. Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA;2. Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA;3. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland;4. Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;5. Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA;6. Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA;7. Research Service, VA Long Beach Healthcare System, Long Beach, CA 90822, USA;8. Department of Clinical Pharmacy Practice, University of California, Irvine, Irvine, CA 92697, USA;9. Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA
Abstract:
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  • Keywords:retinal degeneration  childhood blindness  Lrat  Leber congenital amaurosis  9-cis-retinyl acetate  two-photon calcium imaging  V1  retinoid treatment  binocularity  retinal disease
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