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Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3
Affiliation:1. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;2. Innovative Center for Pathogen Research, Guangzhou Laboratory, Guangzhou 510005, China;3. Laboratory of Structural Biology, Tsinghua University, Beijing 100084, China;4. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300353, China;5. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia;6. CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;7. University of Chinese Academy of Sciences, Beijing 100101, China;8. Shanghai Clinical Research and Trial Center, Shanghai 201210, China
Abstract:
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  • Keywords:MmpL3  drug target  drug design  ST004  mycobacteria
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