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Structural basis of nanobodies neutralizing SARS-CoV-2 variants
Affiliation:1. The CAS Key Laboratory of Receptor Research, Stake Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;2. Department of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China;4. Center for Emerging Infectious Diseases, CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, No. 44 Xiao Hong Shan, Wuhan, Hubei 430071, P.R. China;5. College of Science, Shanghai University, Shanghai 200444, China;6. School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P.R. China;7. University of Chinese Academy of Sciences, Beijing 100049, China
Abstract:
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  • Keywords:SARS-CoV-2 virus  receptor-binding domain  nanobody  crystal structure  bi-paratopic nanobodies
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