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Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor
Institution:1. Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan;2. Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan;3. Membrane Protein Research and Molecular Chirality Research Centers, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan;4. Department of Medical Chemistry, Kansai Medical University, Hirakata 573-1010, Japan
Abstract:
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  • Keywords:G protein-coupled receptor  X-ray crystallography  orexin-2 receptor  molecular dynamics  anti-insomnia drug
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