The plant-unique cis-element that mediates signaling from multiple endoplasmic reticulum stress sensors |
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Authors: | Shimpei Hayashi Fumio Takaiwa |
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Affiliation: | Genetically Modified Organism Research Center; National Institute of Agrobiological Sciences; Tsukuba, Ibaraki, Japan |
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Abstract: | The accumulation of unfolded proteins in the ER lumen induces intracellular signaling mediated by the ER stress sensor protein IRE1. Our recent study identified a new common cis-element of ER stress-responsive genes (such as rice BiP paralogs and WRKY45) that were regulated via an IRE1-dependent pathway. ER stress-responsive cis-elements had been expected to be conserved between plants and mammals. However, contrary to expectations, sequences of the plant cis-element, pUPRE-II, were not identical to those of its mammalian counterpart. Additionally, pUPRE-II also interacted with another ER stress sensor protein and mediated multiple signaling pathways. Here, we provide a summary of the results that suggest the complicated mechanism underlying the regulation of ER stress-responsive gene expression in plants. |
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