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Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state
Affiliation:1. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK;2. School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK;3. Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK;4. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK;5. School of Physics and Astronomy, University of St Andrews, St Andrews KY16 9SS, UK;6. Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9NL, UK
Abstract:
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  • Keywords:lipids  MscL  MscS  mechanosensitive channels  EPR spectroscopy  HDX  MD  ESSEM  mass spectrometry  force-from-lipid
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