Eotaxin and the attraction of eosinophils to the asthmatic lung |
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Authors: | Dolores M Conroy Timothy J Williams |
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Affiliation: | (1) Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, London, UK |
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Abstract: | Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and are believed to be important in the pathogenisis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th)2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor (CCR)3, and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction. |
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