Reaction of carcinogen dimethylnitrosamine with proteins and with thiol compounds in the intact animal |
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| Authors: | Valda M. Craddock |
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| Affiliation: | Toxicology Research Unit, Medical Research Council, Woodmansterne Road, Carshalton, Surrey |
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| Abstract: | 1. [14C]Dimethylnitrosamine was administered to rats, and the formation of free and protein-bound S-methylcysteine was investigated. 2. Very little S-methylcysteine was found in liver acid-soluble fraction, in liver protein or in urine. 3. The methylhistidines formed in liver protein were found to have largely disappeared by 6 days after injection of dimethylnitrosamine. 4. The significance of these results in the carcinogenic action of dimethylnitrosamine is discussed. |
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