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Peripolar cell hypertrophy in the renal juxtaglomerular region of newborn sheep |
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| Authors: | Daine Alcorn Geraldine R Cheshire John P Coghlan Professor Graeme B Ryan |
| Institution: | (1) Department of Anatomy, University of Melbourne, Parkville, Victoria, Australia;(2) Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia;(3) Department of Anatomy, University of Melbourne, 3052 Parkville, Victoria, Australia |
| Abstract: | Summary In the renal juxtaglomerular region of newborn sheep, it was found that glomerular peripolar cells and their granules were very much larger than those found in fetal lambs or adult sheep. Similar peripolar cell hypertrophy was triggered in fetal lambs treated in utero with intraperitoneal injections of dexamethasone. Ultrastructurally, granules of peripolar cells from newborn lambs resembled closely the enlarged zymogen granules described in the pancreas of newborn rats. Such peripolar cell hypertrophy may reflect a functional adaptation of the kidney to immediate postnatal life. |
| Keywords: | Peripolar cells Juxtaglomerular apparatus Newborn sheep Dexamethasone Ultrastructure Cytoplasmic granules |
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