食蟹猴疟原虫感染恒河猴的长期观察

本项研究证明,食蟹猴疟原虫感染恒河猴后出现的红细胞内期是一个长期的寄生过程,不论血传或子孢子感染,于原虫密度高峰后,均有较长期的低原虫密度阶段。恒河猴均可耐受食蟹猴疟原虫高密度的感染。

OBSERVATION ON THE LONG-TERM COURSE OF INFECTION WITH PLASMODIUM CYNOMOLGI IN RHESUS MONKEY

A long-term course of infection with Plasmodium cynomolgi was observed in 8 rhesus monkeys inoculated with trophozoites and in 8 with sporozoites. The course could be as long as more than 2217 days. The parasitemia levels examined by thick blood smears declined in an undulating way after the initial peak; and if the monkey ever survived, a low level of parasitemia was usually observed all along. It was suggested that the special parasitemia was named low parasitic-density stage of erythrocytic period. The gametocytes developed in the other recipient monkey with parasites from such donors did not lose their infectivity to Anopheles Stephensi. Two monkeys recovered spontaneously from the infection. The recrudescence occurred in one monkey after splenectomy, in which the parasitemia had continued at a low density for 886 days, and then become negative in thick blood smears for an additional 384 days. All the infected monkeys could tolerate high parasitemia.