| Abstract: | By means of classical neurohistological techniques, phase contrast microscopy and morphometry, a comparative investigation has been performed concerning the development of the intramural nervous apparatus in the small intestine, normal and at application of cormogrisine. The structural peculiarities of morphogenesis are considered together with signs of activation and inhibition of the neurons growth in tissue culture. A number of morphological criteria, demonstrating an increased extrusive activity and enhancing potensity of the neurons growth have been revealed. The number of nervous processes becomes greater; degree of their ramification increases; a part of neurons of Dogiel II type turns into multiprocessive neurons with some signs of Dogiel I type cells; growth cones and arcadian structures are present; giant processes appear; thick nervous fasciculi are formed; volume of the neuron bodies increases more intensively. After application of cormogrisine for 2 months a definite neurostimulatory effect is revealed; it demonstrates a more intensive morphogenesis of the small intestine nervous of Physiology, USSR, Academy of Medical Sciences, Leningrad. |
