Protein Ionizable Groups: pK Values and Their Contribution to
Protein Stability and
Solubility |
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| Authors: | C. Nick Pace Gerald R. Grimsley J. Martin Scholtz |
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| Affiliation: | Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, Texas 77843 |
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| Abstract: | The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility. |
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