Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin |
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Authors: | N Matsushita Y Kato A Shimatsu H Katakami M Fujino H Matsuo H Imura |
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Affiliation: | 1. Second Medical Clinic, Department of Medicine, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606 Japan;1. Chemical Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku. Osaka 532 Japan;7. Department of Biochemistry Miyazaki Medical College, Kiyotake, Miyazaki 889-16, Japan |
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Abstract: | Intraventricular injections of α-neo-endorphin, β-neo-endorphin and dynorphins (dynorphin[1–13], dynorphin[1–17], dynorphin[1–8]) resulted in an increase in plasma prolactin levels in urethane-anesthetized rats. Dynorphin [1–13] was the most potent to stimulate prolactin release among these opioid peptides. Plasma prolactin responses to these stimuli were blunted by naloxone, an opiate antagonist. In studies, prolactin release from perfused pituitary cells was stimulated by α-neo-endorphin, and the effect was blunted by naloxone, whereas neither β-neo-endorphin nor dynorphin[1–13] affected prolactin release. These results suggest that newly identified “big” Leu-enkephalins in the brain stimulate prolactin secretion in the rat and that α-neo-endorphin has a possible direct action on the pituitary. |
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