Nephrotoxic action of platinum, chromium and cadmium compounds on marine bony fishes

Intra-abdominal injections of platinum, chromium and cadmium salts to Myoxocephalus scorpius produce nephrotoxic effect which includes the disturbances in magnesium secretion. Basic ultrastructural changes in the nephron cells of the fish after the injection of nephrotoxic substances are similar to those in mammals. Cis-platinum induces significant damage in the terminal part of the proximal tubules. One day after the injection of chromium compounds, total damage of the proximal tubule is observed, whereas cadmium salt affects cells within the whole nephron. After 5 days of administration of cadmium and chromium salts, partial recovery was found with respect to both functional and ultrastructural properties of nephron cells. Administration of nephrotoxic substances which selectively injure different parts of the nephron enabled to perform more exact differentiation of the nephron elements in marine teleosts.