The Th1-specific costimulatory molecule,m150, is a posttranslational isoform of lysosome-associated membrane protein-1 |
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Authors: | Prasad Durbaka V R Parekh Vrajesh V Joshi Bimba N Banerjee Pinaki P Parab Pradeep B Chattopadhyay Samit Kumar Anil Mishra Gyan C |
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Affiliation: | National Centre For Cell Science, Pune, India. |
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Abstract: | In an earlier report, we had shown a 150-kDa protein termed as M150, isolated from the surface of activated macrophages, to possess costimulatory activity for CD4(+) T cells. Significantly, this protein was found to specifically elicit Th1 responses. In this study, we characterize M150, which belongs to a unique subset of the lysosome-associated membrane protein-1 glycoprotein. Interestingly, the costimulatory activity of M150 depends on its posttranslational modification, which has a distinct glycosylation pattern restricted to macrophages. Furthermore, it has been demonstrated that in addition to stimulating Th1-specific responses, M150 is also capable of driving differentiation of naive CD4(+) T cells into the Th1 subset. This altered posttranslational modification of housekeeping protein appears to represent a novel pathway by which APCs can additionally regulate T cell responses. |
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