Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia |
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Authors: | Pretsch W |
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Institution: | GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany. pretsch@gsf.de |
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Abstract: | A glutathione reductase (GR) mutant with approximately 50% residual enzyme activity in blood compared with wild-type was detected amongst offspring of isopropyl methanesulphonate-treated male mice. Homozygous mutants with only 2% residual enzyme activity were recovered in progeny of inter se matings of heterozygotes. Results of linkage studies indicate a mutation at the Gr1 structural locus on chromosome 8. The loss of GR activity was evident both in blood and in other tissue extracts. Erythrocyte and organo-somatic indices did not show differences between wild-types and homozygous mutants, indicating no association between the GR deficiency and haemolytic anaemia in this potential animal model. |
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