Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats |
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Authors: | F Sultan D Lagrange H Jansen S Griglio |
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Institution: | INSERM U 177, Institut Biomédical des Cordeliers, Paris, France. |
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Abstract: | 4-14C]Cholesteryl oleyl ether-labeled chylomicron remnants were injected into rats which received a specific goat antibody against rat hepatic lipase or a control serum. Chylomicron remnant cholesterol ether disappeared from circulation with a significantly higher half-life (2-fold) in antibody-treated rats than in controls (P less than 0.001). Recovered radioactivity in the liver was 2-fold lower in antibody-treated rats (22.8% (n = 6) vs. 45% (n = 4) P less than 0.01). These results clearly show that hepatic lipase may strongly promote chylomicron remnant cholesterol ether uptake by the liver. |
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