Constraint-based analysis of metabolic capacity of <i>Salmonella typhimurium</i> during host-pathogen interaction期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

*Constraint-based analysis of metabolic capacity of Salmonella typhimurium* during host-pathogen interaction**

Authors:	Anu Raghunathan Jennifer Reed Sookil Shin Bernhard Palsson Simon Daefler

Affiliation:	(1) Department of Infectious Diseases, Mount Sinai School of Medicine, New York, USA;(2) Department of Chemical and Biological Engineering, University of Wisconsin, Madison, USA;(3) Department of Bioengineering, University of California San Diego, San Diego, USA

Abstract:	Background Infections with Salmonella cause significant morbidity and mortality worldwide. Replication of Salmonella typhimurium inside its host cell is a model system for studying the pathogenesis of intracellular bacterial infections. Genome-scale modeling of bacterial metabolic networks provides a powerful tool to identify and analyze pathways required for successful intracellular replication during host-pathogen interaction.

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