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Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors |
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| Authors: | Perrine Castets Svetlana Maugenre Corine Gartioux Mathieu Rederstorff Alain Krol Alain Lescure Shahragim Tajbakhsh Valérie Allamand Pascale Guicheney |
| Affiliation: | 1. Inserm, U582, F-75013, Paris, France 2. UPMC Univ Paris 06, UMR_S582, Institut de Myologie, IFR14, F-75013, Paris, France 6. Inserm, U956, UPMC Univ Paris 06, UMR_S956, F75013, Paris, France 7. Inserm, U974, Institut de Myologie, CNRS UMR7215, UPMC Univ Paris 06, UMR_S974, IFR14, F-75013, Paris, France 3. Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, F-67084, Strasbourg, France 8. Innsbruck Medical University, Biocenter, Section for Genomics and RNomics, A-6020, Innsbruck, Austria 4. CNRS, URA 2578, Institut Pasteur, F-75015, Paris, France 5. AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Biochimie Métabolique, F-75013, Paris, France |
| Abstract: | BackgroundIn humans, mutations in the SEPN1 gene, encoding selenoprotein N (SelN), are involved in early onset recessive neuromuscular disorders, referred to as SEPN1-related-myopathies. The mechanisms behind these pathologies are poorly understood since the function of SelN remains elusive. However, previous results obtained in humans and more recently in zebrafish pointed to a potential role for SelN during embryogenesis. Using qRT-PCR, Western blot and whole mount in situ hybridization, we characterized in detail the spatio-temporal expression pattern of the murine Sepn1 gene during development, focusing particularly on skeletal muscles. |
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