Effect of demedullation on freezing injury in hind limbs of rats |
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Authors: | Shashi Dhingra B Bhatia G S Chhina Baldev Singh |
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Institution: | (1) School of Environmental Sciences, Jawaharlal Nehru University, 110067 New Delhi, India;(2) Environmental and Nutritional Health Research Organisation, L-23, Hauz Khas Enclave, 110016 New Delhi, India;(3) Department of Physiology, All-India Institute of Medical Sciences, Ansari Nagar, 110029 New Delhi, India |
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Abstract: | Freezing incidence and tissue loss on exposure of hind limbs of female Wistar rats to freezing mixture was reduced by demedullation 6 days prior to cold exposure (p<0.01 and p<0.001 respectively); demedullation 1 h after freezing injury had no effect on tissue loss. Noradrenaline (1 mg/kg i.p.) 5 min before exposure increased the freezing incidence in intact (p<0.05) as well as in demedullated rats (p<0.01), with no effect on tissue loss. Adrenaline (500 mg/kg i.p.) had no effect on either. A sustained fall in plasma adrenaline after demedullation leading to reduced reactivity of the blood vessels to some vasoactive agents is postulated. |
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