Fibroblast growth factors: at the heart of angiogenesis. |
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| Authors: | J. Slavin |
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| Affiliation: | 1. Division of Pediatric Cardiac Surgery, Lucile Packard Children’s Hospital/Stanford University, Stanford, California;2. Division of Pediatric Cardiology, Lucile Packard Children’s Hospital/Stanford University, Stanford, California;1. Institute for Environmental Studies, Charles University in Prague, Benátská 2, Prague, CZ-12801, Czech Republic;2. Institute of Soil Biology and SoWa Research Infrastructure, Biology Centre, Czech Academy of Sciences, Na Sádkách 7, České Budějovice, CZ-37005, Czech Republic;3. Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands;1. University of Wyoming, Department of Animal Science, Dept 3684, 1000 E. University Ave., Laramie, WY 82071, USA;2. Oregon Health and Science University, Department of Physiology & Pharmacology, 3181 SW, Sam Jackson Park Rd., Portland, OR 97239, USA;1. Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium;2. de Duve Institute, Université Catholique de Louvain, Brussels, Belgium;3. Molecular Profiling of Myeloproliferative Neoplasms and Acute Leukemia (MyeloAL) Program, Stefan S. Nicolau Institute of Virology, Bucharest, Romania;4. Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic;5. Department of Clinical Biology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium;6. Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania;7. Department of Radiology, Oncology, and Hematology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;8. Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania;9. Institute of Hematology and Blood Transfusion, Prague, Czech Republic;10. Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;11. Service of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium |
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| Abstract: | Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. In this review the structure and function of the fibroblast growth factor family and its receptors are described. The evidence implicating both FGF-1 and FGF-2 in the control of blood vessel formation is presented and their involvement in normal and pathological angiogenesis during adult life is then described in more detail. |
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