Interaction of filarial proteins on growth regulation of normal lung epithelial cells in vitro期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Interaction of filarial proteins on growth regulation of normal lung epithelial cells in vitro

Authors:	A. Maya S. Usha K. Jayaraman Krishnan Baba M. Sukumaran A. Balakrishnan

Affiliation:	1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Key Laboratory of Chinese Medicinal Resources Recycling Utilization Under National Administration of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China;2. School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China;1. Binzhou Medical University Hospital, Binzhou, 256603, China;2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China;3. Department of Traditional Chinese Medicine, Nanfang Hospital (ZengCheng Branch), Southern Medical University, Guangzhou, 510515, China;4. Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;5. Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510000, China;6. The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, 510000, China;7. School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China;1. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Obstetrics and Gynecology, IVF Unit, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran;4. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Traditional Pharmacy, School of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;7. Physical Medicine and Rehabilitation Research Center, Aging Institute, Tabriz University of Medical Sciences, Tabriz, Iran;8. Instructor, Midwifery Department, Bonab Branch, Islamic Azad University, Bonab, Iran

Abstract:	An in vitro model to examine the effects of filarial proteins on lung epithelial cells has been developed. Several of these proteins appear in circulation of infected individuals. A close association between tropical pulmonary eosinophilia (TPE) and filariasis has been reported by several workers. [³H]-thymidine studies do indicate that when optimum concentration of these filarial proteins were added to lung cultures in proliferating and basal/maintenance media a further increase in growth stimulation was observed early in culture. However, on longer exposures and at higher concentrations an inhibitory effect with distinct morphological changes were noted. The dual role of these proteins on lung epithelial cells in vitro may highlight the possibility of a direct interaction of these proteins with lung cells during disease also contributing to tissue damage.

Keywords:	Lung Epithelial cell culture TPE
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏