Transforming growth factor alpha. |
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| Authors: | V Kumar S A Bustin I A McKay |
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| Institution: | 1. Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada;2. Department of Psychology, University of British Columbia, Vancouver, BC, Canada;3. Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada;2. CNRS, IBS, Grenoble France;3. CEA, IBS, Grenoble, France;4. Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA |
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| Abstract: | Transforming growth factor alpha (TGFα) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGFα, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGFα before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R. |
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