Aberrant glycosylation associated with enzymes as cancer biomarkers |
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| Authors: | Danni L Meany Daniel W Chan |
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| Institution: | (1) Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA |
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| Abstract: | Background One of the new roles for enzymes in personalized medicine builds on a rational approach to cancer biomarker discovery using
enzyme-associated aberrant glycosylation. A hallmark of cancer, aberrant glycosylation is associated with differential expressions
of enzymes such as glycosyltransferase and glycosidases. The aberrant expressions of the enzymes in turn cause cancer cells
to produce glycoproteins with specific cancer-associated aberrations in glycan structures. |
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| Keywords: | Enzyme Aberrant Glycosylation Cancer Biomarkers Glycosyltransferases Glycoprotein Glycan |
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