Crystal structure of <Emphasis Type="Italic">Saccharomyces cerevisiae</Emphasis> 6-phosphogluconate dehydrogenase Gnd1 |
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Authors: | Weiwei He Yi Wang Wei Liu Cong-Zhao Zhou |
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Institution: | (1) Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China |
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Abstract: | Background As the third enzyme of the pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is the main generator of cellular
NADPH. Both thioredoxin reductase and glutathione reductase require NADPH as the electron donor to reduce oxidized thioredoxin
or glutathione (GSSG). Since thioredoxin and GSH are important antioxidants, it is not surprising that 6PGDH plays a critical
role in protecting cells from oxidative stress. Furthermore the activity of 6PGDH is associated with several human disorders
including cancer and Alzheimer's disease. The 3D structural investigation would be very valuable in designing small molecules
that target this enzyme for potential therapeutic applications. |
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Keywords: | |
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