New approach to automated synthesis of oligoribonucleotides |
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Authors: | H Schirmeister R Charubala B S Schulz W Pfleiderer |
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Institution: | Fakult?t für Chemie, Universit?t Konstanz, FRG. |
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Abstract: | The combination of 2'-OH protection in ribonucleosides by the p-nitrophenylethylsulfonyl (NPES) group with the 3'-(beta-cyanoethyl) (N,N-diisopropyl)-phosphoramidite function reveals a new approach to oligoribonucleotide synthesis. The corresponding adenosine and guanosine derivatives have been applied to automated solid phase synthesis with good success. |
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