| 益生菌与幽门螺杆菌对黏膜屏障的影响及其机制的研究进展 |
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| 引用本文： | 祁艳,刘海燕,谭俊,陈代杰.益生菌与幽门螺杆菌对黏膜屏障的影响及其机制的研究进展[J].工业微生物,2019,49(2):51-55. |
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| 作者姓名： | 祁艳 刘海燕 谭俊 陈代杰 |
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| 作者单位： | 复旦大学药学院,上海201203;中国医药工业研究总院,上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203;中国医药工业研究总院,上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203;中国药科大学工学院,南京211198;中国医药工业研究总院,上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203;中国医药工业研究总院,上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203;上海交通大学药学院,上海200240 |
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| 基金项目： | 国家自然科学基金;国家自然科学基金;上海市科技人才计划 |
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| 摘 要： | 消化系黏膜屏障对致病菌有防御功能,但是在根除幽门螺杆菌(H. pylori)过程中会导致黏膜屏障的破坏。大量研究表明,益生菌通过修复上皮细胞以及细胞间连接、减少黏液分泌和炎症反应以及缓解消化道菌群紊乱等方式修复黏膜屏障。本文主要综述幽门螺杆菌对消化系黏膜屏障的损害及其机制,以及益生菌对黏膜屏障损伤的保护及修复机制研究的进展。
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| 关 键 词： | 益生菌 幽门螺杆菌 黏膜屏障 |
Research advances in effects of probiotics and Helicobacter pylori on mucosal barrier and its mechanism |
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| QI Yan,LIU Haiyan,TAN Jun,CHEN Daijie.Research advances in effects of probiotics and Helicobacter pylori on mucosal barrier and its mechanism[J].Industrial Microbiology,2019,49(2):51-55. |
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| Authors: | QI Yan LIU Haiyan TAN Jun CHEN Daijie |
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| Institution: | (School of Pharmacy ,Fudan University, Shanghai 201203, China;State Key Laboratory of New Drug and Pharmaceutical Process, ShanghaiInstitute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry, Shanghai 201203, China;College of Engineering, China Pharmaceutical University, Nanjing211198, China;School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240,China) |
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| Abstract: | The mucosal barrier of the digestive system has a protective function against pathogenic bacteria, but it may be damaged during the eradication of Helicobacter pylori . Numerous studies showed that probiotics repaired the mucosal barrier by repairing epithelial cells and intercellular connections, reducing mucus secretion and inflammation, and alleviating gastrointestinal flora disorders. In this paper, the damage of Helicobacter pylori to mucosal barrier and its mechanism were mainly outlined, as well as the protection and mechanism of probiotics against mucosal barrier injury. |
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| Keywords: | probiotics Helicobacter pylori mucosal barrier |
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