青霉属真菌次级代谢产物的结构类型及其药用活性的研究进展

青霉属(Penicillium)真菌属于腐生类真菌,是自然界中一类重要的分解者。其可以产生多种多样的次级代谢产物。这些结构新颖、功能特殊的次级代谢产物在抗菌、抗氧化、抗肿瘤等药物开发中发挥重要作用,主要由聚酮类、生物碱、萜类、大环内酯等化学结构类型组成。本文综述了青霉属真菌次级代谢产物的结构类型以及丰富的生物药用活性,该内容可为后续青霉属真菌新型天然药物的开发提供研究思路。

Advances in structural types and medical activities of secondary metabolites of Penicillium fungi

As an important class of decomposers in nature, Penicillium fungi belong to saprophytic fungi. It can produce a variety of secondary metabolites. These secondary metabolites with novel structures and special functions have antibacterial, antioxidative and antitumor functions, and are mainly composed of polyketides, alkaloids, terpenoids, macrolides and other chemical structural types. The structural types and biological activities of natural secondary metabolites of the Penicillium fungi were reviewed in this article. Its contents could provide research ideas for the development of new natural medicines from Penicillium fungi.