| 医药中间体L-核糖的生物制造研究进展 |
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| 引用本文： | 黄擎宇,徐铮,李莎,徐虹,蒋云帆.医药中间体L-核糖的生物制造研究进展[J].工业微生物,2019,49(3):61-69. |
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| 作者姓名： | 黄擎宇 徐铮 李莎 徐虹 蒋云帆 |
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| 作者单位： | 南京工业大学食品与轻工学院,南京211816;材料化学与工程国家重点实验室,南京210009;材料化学与工程国家重点实验室,南京,210009 |
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| 摘 要： | L-核糖(L-ribose)是自然界不存在的L-型稀有糖,L-核糖是多种核苷类似物药物的核心砌块,其衍生物2-脱氧-L-核糖也是昂贵的药物中间体;过去只能通过化学合成获得,近年来开始有酶法合成的报道。本文综述了L-核糖生物制备的三种关键酶-L-阿拉伯糖异构酶(L-AI)、甘露糖-6-磷酸异构酶(MPI)、以及L-核糖异构酶(L-RI)在制备L-核糖方面的研究进展,结合产品衍生物研发进行了总结,并展望了L-核糖在未来医药行业的技术需求。
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| 关 键 词： | L-核糖 2-脱氧-L-核糖 生物催化 药物中间体 稀少糖 |
Research progress in bio-manufacture pharmaceutical intermediate L-ribose |
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| HUANG Qingyu,XU Zheng,LI Sha,XU Hong,JIANG Yunfan.Research progress in bio-manufacture pharmaceutical intermediate L-ribose[J].Industrial Microbiology,2019,49(3):61-69. |
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| Authors: | HUANG Qingyu XU Zheng LI Sha XU Hong JIANG Yunfan |
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| Institution: | (School of Food and Light Industry, Nanjing University of Technology, Nanjing 211816;State Key Laboratory of Materials Chemistry and Engineering, Nanjing 210009) |
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| Abstract: | L -ribose is a rare L -type sugar which does not exist in nature. L -ribose is the core block of many nucleoside analogues, and its derivative 2-deoxy- L -ribose is also an expensive pharmaceutical intermediate. In the past, it could only be obtained by chemical synthesis. In recent years, enzymatic synthesis has been reported. Combined with the research and development of product derivatives, research progresses of three key enzymes in the preparation of L -ribose such as L -arabinose isomerase ( L -AI), mannose-6-phosphate isomerase (MPI) and L -ribose isomerase ( L -RI) were outlined in this paper. The technical demand of L -ribose in the future pharmaceutical industry was also prospected. |
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| Keywords: | L -ribose 2-deoxy- L -ribose biocatalysis pharmaceutical intermediates rare sugar |
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