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Mutant tyrosine transfer ribonucleic acids |
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| Authors: | J N Abelson M L Gefter L Barnett A Landy R L Russell J D Smith |
| Affiliation: | 1. College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, Guangdong, China;2. Graduate School of Life and Environment Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan;1. School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, Guangdong, PR China;2. Department of Veterinary Disease Biology, Faculty Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark;3. Research Institute of Food Safety and Nutrition, Jinan University, 510632 Guangzhou, PR China |
| Abstract: | Three independent mutants of the suIII tyrosine suppressor transfer RNA gene have been isolated. These mutants are shown to produce mutant tRNA's differing from the wild-type suIII+ tRNA molecule in each case by a single base change. A mutant tRNA containing an A residue in place of a G in the “dihydrouracil loop” appears to be defective in a step in protein synthesis occurring after the acylated tRNA is bound to the ribosome. A mutant tRNA having an A residue in place of a G in the “anticodon stem” appears to be defective exclusively in its apparent affinity for the tyrosyl tRNA synthetase. The isolation of mutant tRNA's as well as their biological properties are discussed. |
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