Effect of nutrient variations on growth and brefeldin A formation inCurvularia lunata |
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| Authors: | C. T. Sam |
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| Affiliation: | (1) Department of Pharmacy, University of Sydney, 2006 Sydney, New South Wales, Australia;(2) Present address: 2-V, Lorong Delima Sembilan, Island Glades, Penang, Malaysia |
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| Abstract: | The highest level of secreted brefeldin A was present in glucose-grown cultures, intermediate levels in glucose-fructose, and xylose cultures and low levels in fructose- and galaotose-grown cultures ofCurvularia lunata. The biomass decreased from glucose, fructose, xylose, glucose-fructose to galactose cultures. Brefeldin A levels and mycelial yields were low in citrate-, gluconate-, and succinate-grown cultures. Inorganic phosphate-limited cultures supported a high level of brefeldin A. Intermediate levels were present in trace elements-, and inorganic phosphate-trace elements-limited cultures. |
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