BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260 |
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| Authors: | Guo Zekun Tang Wenwen Yuan Jian Chen Xinya Wan Bo Gu Xiuting Luo Kuntian Wang Yingli Yu Long |
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| Institution: | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China. |
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| Abstract: | Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA. |
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| Keywords: | BRSK2 PKA Phosphorylation AMPK subfamily |
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