Loss of 3p or 11p alleles is associated with testicular cancer tumors |
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Authors: | R A Lothe S D Foss? A E Stenwig Y Nakamura R White A L B?rresen A Br?gger |
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Affiliation: | Department of Genetics, Norwegian Radium Hospital, Montebello, Oslo. |
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Abstract: | Constitutional and tumor genotypes defined by polymorphic DNA markers were examined in 31 testicular cancer patients. Constitutional karyotypes were analyzed and clinical data presented. We analyzed 11 loci representing 8 chromosomes, including regions frequently deleted in other types of cancer. Loss of 3p or 11p sequences was detected in 8 of 28 heterozygotes (28%) and in 5 of 20 heterozygotes (25%). This gives a combined total loss of 40%. The other autosomal loci tested showed no loss or a loss of less than 10% of alleles. We suggest that this loss of heterozygosity for genetic material on chromosome 3p or on 11p is nonrandom and important in the development of a major subset of testicular neoplasms. |
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