首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Evolutionary epidemiology of schistosomiasis: linking parasite genetics with disease phenotype in humans
Authors:Tine Huyse  Nele AM Boon  Frederik Van den Broeck  Moustapha Mbow  Anurag Chaturvedi  Lynn Meurs  Filip AM Volckaert  Katja Polman
Institution:1. Laboratory of Biodiversity and Evolutionary Genomics, Biology, KU Leuven, Ch. de Bériotstraat 32, 3000 Leuven, Belgium;2. Unit of Medical Helminthology, Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium;3. Department of Biology, Royal Museum for Central Africa, Leuvensesteenweg 13, 3080 Tervuren, Belgium;4. Unit of Molecular Parasitology, Unit of Veterinary Protozoology, Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium;5. Department of Immunology, University Cheikh Anta Diop, Dakar, Senegal
Abstract:Here we assess the role of parasite genetic variation in host disease phenotype in human schistosomiasis by implementing concepts and techniques from environmental association analysis in evolutionary epidemiology. Schistosomiasis is a tropical disease that affects more than 200 million people worldwide and is caused by parasitic flatworms belonging to the genus Schistosoma. While the role of host genetics has been extensively studied and demonstrated, nothing is yet known on the contribution of parasite genetic variation to host disease phenotype in human schistosomiasis. In this study microsatellite genotypes of 1561 Schistosoma mansoni larvae collected from 44 human hosts in Senegal were linked to host characteristics such as age, gender, infection intensity, liver and bladder morbidity by means of multivariate regression methods (on each parasite locus separately). This revealed a highly significant association between allelic variation at the parasite locus L46951 and host infection intensity and bladder morbidity. Locus L46951 is located in the 3′ untranslated region of the cGMP-dependent protein kinase gene that is expressed in reproductive organs of adult schistosome worms and appears to be linked to egg production. This putative link between parasite genetic variation and schistosomiasis disease phenotype sets the stage for further functional research.
Keywords:Environmental association analysis  Molecular epidemiology  Disease phenotype  cGMP-dependent protein kinase  Follistatin  Parasite fecundity
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号