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The regulation of protein function by multisite phosphorylation--a 25 year update |
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| Authors: | Cohen P |
| Affiliation: | MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee, UK DD1 5EH. |
| Abstract: | The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. ‘Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration. |
| Keywords: | phosphorlyation signal transduction docking SH2 domain kinok |
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