A method for the computation of aortic distensibility in the living human patient and its use for the determination of the aortic effects of aging,drugs, and exercise |
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Authors: | Freeman W Cope |
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Institution: | (1) Aviation Medical Acceleration Laboratory, U.S. Naval Air Development Center, Johnsville, Pennsylvania |
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Abstract: | Detailed equations are given for the computation of aortic distensibility in the intact living human patient from measurements
of systolic and diastolic arterial pressures, heart rate and cardiac output. From these equations, the aortic characteristics
of a large series of normal men of different ages were computed. Comparing these results with measurements on excised aortas,
a more pronounced trend toward increasing aortic stiffness with increasing age is evident in living than in dead aortas. Nor-epinephrine
and exercise apparently cause the living aortas to constrict but to become more distensible. The same change occurs after
30 minutes of high spinal anesthesia. The ganglionic blocking agents hexamethonium, pentamethonium, and tetraethylammonium
usually cause the living aorta to become stiffer, presumably due to dilatation. The aortas of patients with pulmonary disease
usually react in different fashion to exercise or tetraethylammonium. The increased aortic distensibility that occurs with
the hypertension induced by nor-epinephrine or exercise acts as a compensatory mechanism by decreasing systolic pressure.
Opinions and conclusions contained in this report are those of the author. They are not to be construed as necessarily reflecting
the views or the endorsement of the Navy Department. |
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