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Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A |
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| Authors: | Nunzia Migliaccio Nicola M Martucci Immacolata Ruggiero Carmen Sanges Shinji Ohkubo Annalisa Lamberti Enzo Agostinelli Paolo Arcari |
| Institution: | 1.Department of Molecular Medicine and Medical Biotechnology,University of Naples Federico II,Naples,Italy;2.ERT, Research Technology GmbH,Estenfeld,Germany;3.Department of Biochemical Sciences “A. Rossi Fanelli”,“SAPIENZA” University of Rome,Rome,Italy;4.CEINGE, Advanced Biotechnology Scarl,Naples,Italy |
| Abstract: | The link between eukaryotic translation elongation factor 1A (eEF1A) and signal transduction pathways through the regulatory mechanism of phosphorylation has never been considered. In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and apoptosis. In this context, polyamines seem to play a role in the regulation of the translation elongation process by modulating the Ser/Thr kinases involved in the phosphorylation of translation elongation factors. |
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