1H NMR study on the conformation of bacitracin A in aqueous solution. |
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Authors: | N Kobayashi T Takenouchi S Endo E Munekata |
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Institution: | Institute of Applied Biochemistry, University of Tsukuba, Japan. |
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Abstract: | The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1-6) is folded over the cyclic ring, resulting in metal coordination sites, a thiazoline ring, and Glu4 and His10 being proximate to each other. |
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