| 利用分子进化树计算蛋白质的特异进化速率 |
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| 引用本文： | 卢柏松 黄培堂. 利用分子进化树计算蛋白质的特异进化速率[J]. 遗传学报, 1996, 23(2): 85-90 |
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| 作者姓名： | 卢柏松 黄培堂 |
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| 作者单位： | 北京军事医学科学院生物工程研究所 |
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| 摘 要： | 本文提出了一种计算蛋白质绝对进化距离和进化速率的方法，它根据现有同源蛋白质的序列构建分子进化树，并推断进化过程中各结点处的共同祖先序列，根据某成员与某结点处共同祖先序列的氨基酸差异百分率，计算该蛋白质序列的特异进化距离和进化速率。比较我们的算法和Ｄａｙｈｏｆｆ等的模拟统计方法表明，我们的算法在一定范围内是正确的。结合计算哺乳动物红细胞生成素的进化速率，讨论了本算法在分子进化研究中的应用。
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| 关 键 词： | 蛋白质进化，共同祖先序列，分子进化树，绝对进化速率 |
Calculation of Specific Evolution Rate of Prateins Based on Phylogenetic Trees |
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| Lu Baisong,Huang Peitang. Calculation of Specific Evolution Rate of Prateins Based on Phylogenetic Trees[J]. Journal of Genetics and Genomics, 1996, 23(2): 85-90 |
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| Authors: | Lu Baisong Huang Peitang |
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| Affiliation: | Institute of Biotechnology Academy of Military Medicine Sciences Beijing 100850 |
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| Abstract: | A method of calculating specific protein evolution distance and evolution rate is presented.This is based on the reconstruction of the phylogenetic tree and on the deduction of ancestral sequences according to temporally homologous protein sequences.The evolution distance and evolution rate are calculated from the difference percentage of the sequence between the temporal and deduced ancestral sequences.A comparison with Dayhoffs simulation method and an example of using it to calculate the specific evolution rates of mammalian erythropoietin.The method presented here would be specially useful under certain circumstances. |
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| Keywords: | Protein evolution Ancestral sequence Molecular Phylogenetic tree pecific evolution rate |
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