An experimental analysis of factors affecting the localization of embryonic bone marrow |
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| Authors: | Nicholas L Petrakis Susetta Pons Rose E Lee |
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| Institution: | (1) The Department of Epidemiology and International Health, University of California School of Medicine, San Francisco, California;(2) Present address: Laboratorio di Radiobiologia Animale, Casaccia, Comitato Nationale per Energia Nucleari, Rome, Italy |
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| Abstract: | Summary The present investigations have been concerned with factors which determine and influence the localization and development
of hemopoietic bone marrow in the embryo mouse and the adult. These studies, which have employed organ cultures and the transplantation
of mouse embryo femur and tail rudiments, indicate that the surrounding mesenchyme is required for the normal development
of the cartilage rudiment and its ossification, and for the formation and colonization of the marrow cavity. It was suggested
that hemopoiesis results from the colonization of the “prepared” marrow cavity by stem cells arising from sources external
to the rudiment. The addition of erythropoietin and L-thyroxine produced distinct erythropoietic differentiation in the normally
myelocytic embryonic marrow cavity. The significance of the microenvironment present in developing bone rudiments and the
initiation of hemopoiesis in stem cells was discussed.
A hypothesis was developed to explain marrow localization in adults based on the colonization of bone rudiments which are
developing their marrow sites at a time when the blood contains large numbers of colony-forming units. |
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