| 以DL-丝氨酸为原料制备D-丝氨酸的新方法 |
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| 引用本文： | 吴刘洋,蒋立建,李建俊,喻明军. 以DL-丝氨酸为原料制备D-丝氨酸的新方法[J]. 氨基酸和生物资源, 2007, 29(2): 40-41. DOI: 10.3969/j.issn.1006-8376.2007.02.013 |
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| 作者姓名： | 吴刘洋 蒋立建 李建俊 喻明军 |
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| 作者单位： | 东南大学化学化工系,江苏,南京,210096;东南大学化学化工系,江苏,南京,210096;东南大学化学化工系,江苏,南京,210096;东南大学化学化工系,江苏,南京,210096 |
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| 摘 要： | 以DL-丝氨酸为原料经过酯化、拆分和水解制备D-丝氨酸。使L-2,3-二苯甲酰酒石酸(L-DBTA)与DL-丝氨酸甲酯在无水乙醇中于60℃反应形成非对映体盐,冷却到0℃,D-丝氨酸甲酯.L-DBTA二盐析出,过滤后再经水解,得到D-丝氨酸,总收率为74.8%,旋光纯度达到98%以上。
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| 关 键 词： | DL-丝氨酸甲酯盐酸盐 D-丝氨酸甲酯·L-DBTA二盐 拆分 D-丝氨酸 |
| 文章编号： | 1003-8376（2007）02-0040-02 |
| 修稿时间： | 2007-01-22 |
A New Method for the Preparation of D-Serine from DL-Serine |
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| WU Liu-yang,JIANHG Li-jian,Li Jian-jun,YU Ming-jun. A New Method for the Preparation of D-Serine from DL-Serine[J]. Amino Acids & Biotic Resources, 2007, 29(2): 40-41. DOI: 10.3969/j.issn.1006-8376.2007.02.013 |
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| Authors: | WU Liu-yang JIANHG Li-jian Li Jian-jun YU Ming-jun |
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| Affiliation: | 1. Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China |
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| Abstract: | A new method for the preparation of D-serine from DL-serine was tested.Reaction of DL-serine and methanol in the presence of SOCl2 obtained DL-serine methyl ester.The ester reacted with L-2,3-dibenzoyl tartaric acid in ethanol at 60℃ formed L-serine and D-serine methyl ester L-2,3-dibenzoyl tartrate,which precipitated from the mixture when the solution was cooled to 0-5℃.Hydrolysis of D-serine methyl ester L-2,3-dibenzoyl tartrate gave D-serine with yield of 74.8% and optical purity 98%. |
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| Keywords: | DL-serine methyl ester chloride D-serine methyl ester L-2 3-dibenzoyl tartrate resolution D-serine. |
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