低氧暴露条件下高原鼠兔和大鼠HPA轴活动的比较

采用人工模拟低气压低氧的方法比较研究了不同程度（模拟海拔5 km和7 km)和不同时间（24d和5d）低氧暴露，对大鼠和高原鼠兔（Ochotona curzoniae）下丘脑-垂体-肾上腺皮质 (hypothalamo-pituitary-adrenalcortex,HPA)轴活动的影响。结果如下：7 km低氧暴露24 h,大鼠下丘脑的促肾上腺皮质激素释放激素（corticotropin-releasing actor,CRF）和肾上腺皮质激素皮质酮分泌显著增加，大鼠HPA低氧暴露对大鼠HPA 轴活动无显著差异。低氧暴露5天后，大鼠7 km、5 km组的HPA轴活动与对照相比无明显差异。低氧暴露对高原鼠兔的HPA轴无明显影响。上述结果表明：低氧暴露的时间和程度与大鼠HPA的活动密切相关；从HPA的活动来看，高原鼠兔表现出较强的低氧耐受性。

Study of Activity of HPA in Rat and Ochotona curzoniae Under Hypoxia

The effects of hypoxia exposure on activity of hypothalamo pituitary adrenalcortex (HPA) axis in rat and Ochotona curzoniea (O curzoniea) were comparatively studied. Results showed as follow. Hypoxia with 7 km altitude exposed for 24 h resulted in increased corticotropin releasing factor (CRF) release from hypothalamus and corticosterone secretion in rat, the activity of HPA was stimulated by hypoxia. Hypoxia with 5 km altitude exposed for 24 h did not significantly influence the activity of HPA in rat. Hypoxia exposed for 5 d, the activity of HPA was not marked different from control. Hypoxia did not significantly modulate activity of HPA in O curzoniea . These results suggested that activity of HPA was related to extent and time of hypoxia exposure. Hypoxia did not active HPA in O curzoniea and O.curzoniea is more tolerance to hypoxia than rat.