| Schistosome resistance to praziquantel: Fact or artifact? |
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| 引用本文： | Fallon PG,Tao LF,Ismail MM,Bennett JL. Schistosome resistance to praziquantel: Fact or artifact?[J]. Parasitology today (Personal ed.), 1996, 12(8): 316-320. DOI: 10.1016/0169-4758(96)10029-6 |
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| 作者姓名： | Fallon PG Tao LF Ismail MM Bennett JL |
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| 摘 要： |
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Schistosome resistance to praziquantel: Fact or artifact? |
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| Fallon P G,Tao L F,Ismail M M,Bennett J L. Schistosome resistance to praziquantel: Fact or artifact?[J]. Parasitology today, 1996, 12(8): 316-320. DOI: 10.1016/0169-4758(96)10029-6 |
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| Authors: | Fallon P G Tao L F Ismail M M Bennett J L |
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| Affiliation: | Department of Pathology, University of Cambridge. Tennis Court Road, Cambride, UK. pgf@mole.bio.cam.uk |
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| Abstract: | Praziquantel is the current drug of choice for human schistosomiasis. Recent reports from laboratory and field studies concerning reduced praziquantel efficacy against Schistosoma mansoni have generated some controversy. The prevailing question is whether the emergence of strains of schistosome resistant to praziquantel is a fact, or an artifact resulting from erroneous field or laboratory experimentation. In this article, Padraic Fallon, Liang-feng Tao, Magdi Ismail and James Bennett examine the available evidence for schistosome resistance to praziquantel. Contributory factors to the schistosomicidal activity of praziquantel, which may interfere with evaluation of drug efficacy or resistance, are also considered. |
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