Molecular domains of myelinated axons |
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Authors: | Peles E Salzer J L |
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Affiliation: | Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel. peles@weizmann.ac.il |
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Abstract: | Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na(+) channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K(+) channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged. |
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