Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis,to the pter-q12 region of chromosome 6 |
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| Authors: | H T Cuypers G Selten A Berns A H M Geurts van Kessel |
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| Institution: | (1) Department of Biochemistry, University of Nijmegen, GeertGrooteplein N21, NL-6525 EZ Nijmegen, The Netherlands;(2) Department of Cell Biology and Genetics, Erasmus University, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, The Netherlands;(3) Present address: Department of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam, The Netherlands;(4) Department of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam, The Netherlands |
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| Abstract: | Summary Viral leukemogenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called Pim-1. Here we report the chromosomal localization of the human homologue by Southern blot analyses of DNAs obtained from human-rodent somatic cell hybrids. The single copy human homologue was assigned to the 6pter-q12 segment. |
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