Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A |
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Authors: | Oshimi Shiori Tomizawa Yuichiro Hirasawa Yusuke Honda Toshio Ekasari Wiwied Widyawaruyanti Aty Rudyanto Marcellino Indrayanto Gunawan Zaini Noor Cholies Morita Hiroshi |
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Institution: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. |
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Abstract: | A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassiarin A (3) with an unprecedented tricyclic skeleton, supporting a biogenetic pathway proposed for 3. |
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