Cubyl amides: novel P2X7 receptor antagonists |
| |
| Authors: | Gunosewoyo Hendra Guo Jun Liu Bennett Maxwell R Coster Mark J Kassiou Michael |
| |
| Affiliation: | School of Chemistry, University of Sydney, NSW 2006, Australia. |
| |
| Abstract: | Polycyclic amides 2 and 5-9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
